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Insulin directs the muscle and fat cells to take in glucose where it is utilized for energy

This difference in CV benefit observed in the trials has important clinical implications regarding how to use the two classes of agents and how to identify suitable patients to obtain the best benefit from each class during routine diabetes care, possibly leading to a treatment plan tailored to an individual patients CV risk and clinical condition

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While no direct clinical link has yet been established, the report authors propose several mechanisms that could explain a potential link between high-dose semaglutide and optic nerve ischaemia