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Beginning in 2008, extensive cardiovascular outcome trials (CVOTs) were conducted to evaluate the safety and efficacy of novel glucose-lowering agents

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Lactate Dehydrogenase (LDH) Assay The relative amounts of LDH released into the media (conducted in triplicates for each group) were determined using CytoTox-ONE Homogeneous Membrane Integrity Assay kit Cat.#G7892 (Promega, USA) according to the manufacturers instructions

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Its closest competitor, danuglipron from Pfizer, was discontinued in 2025 after one participant experienced possible drug-related liver injury during dose studies, and earlier trials showed high rates of stomach side effects