424 In AD, GLP-1(7-36) amide inhibits IL-1 transcription and prevents cognitive dysfunction, amyloid precursor protein synthesis, and cell death
If you are losing weight at a satisfactory rate on 8mg with minimal side effects, staying at 8mg is a perfectly valid choice
Levels of circulating semaglutide determine reductions in HbA1c and body weight in people with type 2 diabetes
Headache medication might help with the pain, but speak to a medical professional beforehand to ensure it is safe to take with a GLP-1 medication
Kissileff HR, Thornton JC, Torres MI, Pavlovich K, Mayer LS, Kalari V et al
For type 2 diabetes , NICE guideline NG28 recommends considering GLP-1 agonists as an option when: Triple therapy with metformin and two other oral drugs is ineffective, not tolerated, or contraindicated The person has a BMI 35 kg/m (or 32.5 kg/m in people of South Asian or related ethnicity) and specific psychological or medical problems associated with obesity Insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities Treatment should be continued only if there is a beneficial metabolic response (HbA1c reduction of at least 11 mmol/mol [1.0%] and weight loss of at least 3% of initial body weight at 6 months)