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Description

Metabolic and cardiovascular benefits with combination therapy of SGLT-2 inhibitors and GLP-1 receptor agonists in type 2 diabetes

Cell 157 , 15351551 (2014)

Dev Cell

A study revealed that TMAO synergizes with gut-derived lipopolysaccharides (LPS) to amplify NF-B activation in dendritic cells, enhancing Th17 differentiation and IL-17 production, which are critical drivers of mucosal damage in UC (102, 103)

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Factors affecting efficacy include existing endothelial function, individual amino acid metabolism, comorbidities (diabetes, metabolic syndrome, prior cardiovascular events), and - critically - dose