Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]
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In hepatocytes, triiodothyronine (T3) binding to THR- stimulates -oxidation, increases LDL receptor expression, improves mitochondrial function in hepatic cells, boosts very-low-density lipoprotein (VLDL) secretion, and enhances reverse cholesterol transport, thereby reducing lipotoxicity and inflammation [3, 16]
