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For people with raised NF-B levels, the nuclear factor NF-kappa-B (NF-B) transcription factor family is a therapeutic target since it plays a role in several inflammation-driven chronic disorders

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Research has shown a strong correlation between the gut microbiota and the pathophysiology of depression and anxiety (143146)

Researchers also use NNMT inhibitors to probe links between nicotinamide metabolism and epigenetic methylation capacity, depending on the experimental system