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40,41 Similarly, twice-daily topical application of a lotion containing aminophylline, caffeine, yohimbe, L-carnitine, and gotu kola, combined with exercise and restricted calorie intake for 28 days effectively reduced body mass, fat mass, and circumference in the treated area

Such modification alters the essential intramolecular and intermolecular interactions (van der Waals forces, hydrogen bonding, and - stacking) between proteins and nucleic acids, ultimately affecting the structure and function of target proteins [2,3]

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In the same dataset, 47 repair-related genes were turned up by at least 50%, while only five were turned down. GHK-Cu also appears to support antioxidant activity and helps cells handle copper more safely, which matters because unregulated copper contributes to the kind of oxidative stress linked to visible aging. Its effects reach beyond the skin, too