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Studies have shown that TCA cycle activity decreases significantly with age, which directly leads to an imbalance in the NAD+/NADH redox state and a decrease in the intracellular NAD+ level [81]

Many of these symptoms are also present in the thiamine deficiency states (137), supporting involvement of ACP2 in thiamine metabolism

Older individuals are more closely connected to a history that has spurred skepticism of trial research, but this doesnt mean that young people of color are unaffected

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