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Binding mechanism: Unlike peptides that bind to both the ECD and TMD, small-molecule agonists primarily interact with an allosteric binding site within the TMD

Aravinda S, Gopalakrishnan B, Dey CS et al (1995) A testicular protein important for fertility has glutathione S-transferase activity and is localized extracellularly in the seminiferous tubules

Researchers are now applying similar allosteric targeting strategies to the glucagon receptor, the GIP receptor, the PTH receptor, and the calcitonin receptor

Psoriasis can be both physically and psychologically debilitating