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Semaglutide has more GI side effects because it is stronger, so it's important to be careful when you dose it

Glu9 of the GLP-1 forms a direct hydrogen bond with Tyr152, an ionic interactions with Arg190, and a water mediated hydrogen bond with Tyr241

Similar relative bioavailability of semaglutide was shown for IcoSema dosing versus semaglutide dosing alone, as the 90% CI for the ratio of total semaglutide exposure after single dose (AUC 0 t ,SD,Semaglutide ) between IcoSema and semaglutide alone was fully contained within the bioequivalence acceptance interval of [0.80;1.25]

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Left untreated, a severe deficiency can cause permanent nerve damage