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[Abstract] Direct interaction between CAPNS1 and CRBN was assessed by incubating purified GST, GST-CRBN, or GST-neurogranin proteins with glutathione agarose for 3 hours
These changes induce insulin resistance and mitochondrial dysfunction, eventually leading to metabolic disorders and obesity
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Blood-brain barrier insulin resistance decreases insulin uptake and increases amyloid beta uptake in Alzheimers disease brain
On the other hand, structured eating patterns improve hormone signaling
Patients were maintained at their dose for a minimum of 2 weeks before being gradually tapered down to 0.1 mg/day at the last week of treatment
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