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It reduces methemoglobin to hemoglobin by donating electrons via the NADPH-methemoglobin reductase system

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Activated kinases, such as ERK and Akt, can regulate ER activity through phosphorylation 81 , supporting the observed differential effects of BPA on ER-mediated gene expression of estrogen target genes

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In the United States, spironolactone is FDA-approved to treat high blood pressure, heart failure, and fluid retention (edema)