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Overall, these findings indicate that targeting both GIPR and GLP-1R in the CNS with peptideantibody conjugates, enabling GIPR blockade together with GLP-1R agonism, enhances weight loss

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Conducting positional scanning to identify critical residues: Traditionally executed using an l-alanine scan, positional scanning involves substituting each side chain with the smallest alternative while maintaining a similar conformational profile to evaluate its importance for biological activity