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High homocysteine can cause oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress

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Statistical Analysis Statistical analysis was performed by parametric one-way analysis of variance (ANOVA), with post-hoc NewmanKeuls test and non-parametric KruskalWallis test and subsequently the MannWhitney U test to compare groups

At the cellular level, hispidulin inhibited the activation of mitogen-activated protein kinases (MAPKs) in keratinocytes, leading to reduced cell proliferation and inflammation