Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases
If these toxins are released into the bloodstream faster than your primary exit routes can handle, you may experience a temporary "healing crisis" or a Herxheimer-like reaction
Interestingly, a positive feedback loop between miR526b/655 and oxidative stress was identified in breast cancer, and the loop promotes tumor growth and metastasis [67]
On the other hand, ferroptotic endometrial stromal cells can release inflammatory cytokines and activate downstream regulatory pathways to promote proliferation and angiogenesis in surrounding tissues
Curr Neuropharmacol
However, oxidative stress induces phosphorylation and downregulates IB, an apoptosis antagonist, but the activated NF-B promotes cell proliferation and produces cancers [55,56,57,58]