GLP-1 agonists act to manage metabolism in patients by lowering serum glucose levels
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Upon activation, VDR typically forms a heterodimer with RXR, and this complex binds with high affinity to Vitamin D response elements (VDREs), typically of the DR3 type(a direct repeat of the hexameric core sequence separated by three nucleotides), located in promoters or enhancers of target genes via a zinc fingercontaining DNA-binding motif [116].The VDRRXR complex then utilizes its AF-2 domain to recruit coactivators/corepressors and chromatin remodeling enzymes, orchestrating precise transcriptional programs involved in cell proliferation, differentiation, immune homeostasis, antioxidant defense, and barrier function [117,118,119,120].Given that the skin is a frontline environmental sensor chronically exposed to UV radiation, pathogens, and oxidative stress, the ability of VDR to bridge environmental cues and gene expression is particularly critical in this context
doi: 10.1038/s41467-023-39996-z
doi: 10.3892/br.2016.720 139 BhuiKGeorgeJShuklaY
Healthcare providers typically recommend gradual dose titration and dietary modifications to minimize gastrointestinal distress
