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Its dual mechanism appears to give it an edge for many patients (Source: NEJM, SURMOUNT-5 head-to-head trial, which found tirzepatide led to greater weight loss than semaglutide at 72 weeks)

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The activation of IGF-1 and IGF-1R is associated with cell differentiation, proliferation, and apoptosis, linking them to the onset and progression of cancer, as well as poor survival outcomes [109]

If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day

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