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This metabolic suppression occurs because synthetic hormones bypass the hypothalamic-pituitary-thyroid axis and do not trigger the same cellular feedback loops
Diseases like heart disease are exacerbated by stress and stress hormones like cortisol and those of the sympathetic nervous system
But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume
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2012;97:E917E924
Thyrotrophs These cells release thyroid-stimulating hormone (TSH), which regulates thyroid hormone production
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