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Heart rate was continuously monitored using the Polar H10 heart rate monitor, a widely trusted device known for its high accuracy and reliability in tracking cardiovascular responses during exercise

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Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications increasingly prescribed for type 2 diabetes management and, more recently, for weight loss

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This cell type specificity represents a critical factor in understanding SIRT1s diverse roles in MASLD and explains why systemic SIRT1-directed interventions may yield divergent or inconsistent findings