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Violation of the integrity of the intestinal barrier and its improper functioning can result in the uncontrolled passage of bacterial components, products of bacterial metabolism, and harmful substances, thus leading to systemic inflammation

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells

They also prevent the degradation of bradykinin, a vasodilator, and decrease aldosterone levels, which normally raise blood pressure by increasing serum sodium

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