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The antibodies against histamine receptors were purchased from Abgent (H 1 receptor: AF3587a, H 2 receptor: AF2455a), the antibody against CD117 was purchased from Thermo Fisher Scientific (MA-170079), and the antibody against mucin-2 was purchased from Santa Cruz (Sc-15334)

459,460 However, covalent conjugation also has drawbacks

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G/D-CuP could have superior efficacy in modulating inflammatory factors compared to G/M-CuP, likely due to the multivalency effect of dimeric copper peptides, which enhanced the activity

Their mechanisms of action include activating GLUT4 and inhibiting NF-B

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