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Research has shown that even non-GLP-1RA agents have appetite-suppressing effects and can improve obesity (Newgard et al., 2009) or compare insulin-sensitive and insulin-resistant individuals (Tai et al., 2010), and are associated with the persistence of childhood obesity (Wu et al., 2024)

doi: 10.1016/S0140-6736(19)32472-9

That's based on a previous head-to-head clinical trial comparing the highest doses of Zepbound to the 1.7- and 2.4-milligram doses of Wegovy

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