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There are complex scenarios in which WES must be expanded to whole-genome sequencing (WGS)thus engaging with the remaining 98.5% of the genomewhen intronic regions of potential clinical relevance are suspectedfor instance, non-exonic pathogenic variants (Hiraide et al., 2022)

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Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. Oxidative medicine and cellular longevity vol

Direct verification by targeted proteomics (MRM / PRM) is a major contribution beyond simple dendritic Golgi counting