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Symptoms like dizziness, confusion, and weakness may occur, and long term use could contribute to insulin resistance, increasing the risk of metabolic disorders

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Therefore, a novel composite system integrating soluble microneedles with targeted nanoparticlestermed a nanoparticle-microneedle delivery platformholds significant potential for effective and sustained treatment of RA

Clinical evidence from integrative medicine journals suggests combination protocols produce 1.52 greater fat mass reduction compared to diet alone, though large-scale RCTs are lacking