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Alpha lipoic acid is usually well tolerated but side effects at higher doses can include abdominal discomfort, heartburn, constipation or diarrhea, nausea, dizziness, and headache

Injecting water slowly down the inner wall of the vial prevents mechanical shear stress that denatures peptide structure

Adding an SGLT2 inhibitor or basal insulin can enhance glycemic control

doi: 10.1111/j.1365-2672.2010.04671.x 106 MukherjeeA.LordanC.RossR

However, clinical outcomes are complicated by behavioral factors, including lower adherence rates reported among women, which may obscure the true extent of sex-related efficacy differences [52]

Journal of Experimental Botany 57, 16571665