retatrutide triple agonist glp-1 gip glucagon phase 2 trial obesity First-in-Class 'Triple-G'! Retatrutide, a first-in Dual and Triple Gut Peptide

Bacteriostatic Water is avoided in neonates because the benzyl alcohol preservative can be toxic to infants

If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable

Should retatrutide receive a positive regulatory decision, it would then be subject to a health technology appraisal (HTA) by NICE (National Institute for Health and Care Excellence) to determine its clinical and cost-effectiveness relative to existing treatments

Physiological Relevance: Its still debated whether GLP-3 has significant independent biological activity or if its primarily a byproduct of proglucagon processing

2007 Jun;56(6):1671-9

MEDVi states there is no long-term commitment