Importantly, post-translational modification by tTG and PAD is likely to occur more frequently in CD and RA patients given that the removal of apoptotic cellular debris is impaired (Cupi et al
63,65,66,70 Meta-analysis, epidemiological, and clinical follow-up studies have all shown a strong correlation between AKI episodes and subsequent development of CKD
Hayashi H, Sato W, Kosugi T et al (2017) Efficacy of urinary midkine as a biomarker in patients with acute kidney injury
Mount Sinai
[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders
Higher doses do not always produce better results