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Thus, NTS1 activation may modulate alcohol-related behaviors by inhibiting D2R signaling in striatopallidal MSNs in the NAc (Figure 2B), but not in the dorsal striatum where stimulation of NTS1 may promote dopamine signaling

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The underlying mechanism has not been investigated fully yet, however, Pycnogenol s validated effects on blood circulation and endothelial health are good explanations for its beneficial effects on symptoms like hot flashes and sexual behavior