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110 Similar to beta-cells, alpha-cells rely on ATP-dependent K + (KATP) channels to play a key role in promoting exocytosis of intracellular granules, as they couple flux of glucose concentration in circulation to changes in membrane potential and calcium influx

In 2014, the sponsor filed a dispute resolution request, leading to intervention by senior FDA leaders

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J Clin Invest 101: 515-520, 1998

1 Introduction Exercise is an effective non-pharmacological intervention that improves cardiovascular health and function