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These proteins bind to IGF-1 in circulation with an equal or greater affinity than that of the IGF-1R (k d ~10 10 M vs

However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect ( 2 complex with platinum drugs

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PMID: 39336797 FEBS Lett miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells

2018 Feb 5 [cited 2019 Apr 16];9

10.1155/2017/6405278 Oxid Med Cell Longev