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El IGF-1 LR3 es un agonista directo del receptor de IGF-1: evita por completo la hipfisis y el hgado y acta directamente sobre los receptores de IGF-1 en los msculos, la grasa y el tejido conectivo

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In skeletal muscle fibers, excitationcontraction coupling leads to the release of calcium from the sarcoplasmic reticulum and increases intracellular calcium concentrations (Stamler and Meissner, 2001)