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Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site

These studies mark the first administration of a drug candidate to human subjects and provide the initial clinical evidence needed to guide subsequent phases of development

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Calandre EP, Rico-Villademoros F, Slim M

DCs express several receptors for AGEs (RAGE) (195), including galectin-3 (196)

10.1159/000528422 Summary Keywords ketogenic diet, skin, acne, psoriasis, hidradenitis suppurativa, skin cancer Citation Chyliska N and Maciejczyk M (2025) Effects of the ketogenic diet on skinpotential benefits and risks