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Notably, treatment with HMGB1 monoclonal antibody exhibits dual therapeutic effects: (1) inhibiting neuroinflammation, and (2) reducing the release of active HMGB1 from neurons and its intracellular translocation, thus disrupting the HMGB1-mediated inflammatory positive-feedback loop

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J Zhejiang Univ Sci B 16:948956 Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC (2003) Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase

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