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It should document a BMI of 30 or higher (or 27-plus with a comorbidity like hypertension, type 2 diabetes, dyslipidemia, or sleep apnea), failed diet and exercise, and cardiovascular or metabolic risk

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[ref open access] Why could the risk be greater during infancy

For this reason, tirzepatide has shown promising results in clinical trials for chronic weight management

What research has explored: Published studies in journals including Metabolism and the Journal of Ethnopharmacology have examined berberine in the context of glucose metabolism, insulin sensitivity, and metabolic signaling pathways

And these are not just anecdotal