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Bacteriostatic water offers several advantages over alternatives: pH range of 5.0-7.0 prevents acid- or base-catalysed hydrolysis Benzyl alcohol at 0.9% concentration inhibits bacterial growth without denaturing peptides Multi-dose vials remain stable for 28 days under refrigeration (2-8C) No ionic species that could interfere with downstream analytical techniques (HPLC, mass spectrometry) Some UK suppliers provide pre-mixed solutions, but these introduce variables that complicate dose precision

International journal of clinical pharmacology research

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As for highly hydrophobic samples, weakly hydrophobic ligands are desirable to avoid harsh and possibly denaturing elution conditions