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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

And the other sources of peptides, which are gray market and black market, oftentimes do contain the same peptide that one would get from a prescription from a board certified physician, but very often they haven't cleaned out the Lipopolysaccharide

Some patients believe they can find their own ideal dose through trial and error, starting low and adjusting as needed

D., Protein Losing Enteropathy: Comprehensive Review of the Mechanistic Association With Clinical and Subclinical Disease States, Clinical and Experimental Gastroenterology 10 (2017): 147168

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