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Although ponatinib is an FDA-approved TKI that directly targets T315I-Bcr-Abl leukemia, its association with cardiovascular toxicity is a significant concern in clinical therapy

doi: 10.1186/s12974-015-0318-4

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Mitochondria are biosynthetic hubs for essential iron cofactors such as iron-sulfur (Fe-S) clusters and heme

The enhancement of Nrf2 transcription with sulforaphane or melatonin could benefit patients with LONG COVID (Post-Acute Sequelae of SARS-CoV-2 or Post-COVID-Syndrome), a significant proportion (approximately 40%) of individuals with COVID-19 experiencing a variety of symptoms (loss of smell and/or taste, fatigue, cough, aching pain, brain fog, insomnia, shortness of breath, and tachycardia) after 12 weeks (Jarrott et al., 2022