Abbreviations aHR: Adjusted hazard ratio BMI: Body mass index CI: Confidence interval DPP-4i: Dipeptidyl peptidase-4 inhibitor HCC: Hepatocellular carcinoma HER: Electronic health record GLP-1RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare organization ICD-10-CM: International classification of diseases, tenth revision, clinical modification ICD-10-PCS: International classification of diseases, tenth revision, procedure coding system MALO: Major adverse liver outcome MASLD: Metabolic dysfunction-associated steatotic liver disease NAFLD: Nonalcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis PSM: Propensity score matching SD: Standard deviation SGLT2i: Sodiumglucose cotransporter-2 inhibitor T2D: Type 2 diabetes TZD: Thiazolidinedione References Yu M, Zhao S, Fan X, Lv Y, Xiang L, Li R
A further subgroup analysis was performed only for body weight parameters (that is, TBWL%, waist circumference, BMI and proportion of patients achieving at least 5%, 10%, 15%, 20% and 25% of body weight reduction) in RCTs specifically designed for body weight reduction
Researchers interested in investigating tesamorelin for weight loss may also consider initiating the therapy with lower doses for the first 4 weeks of the trial to assess subject tolerance, before increasing the dose to up to 2mg/daily
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10.1016/0300-483X(89)90076-0 8
