Perez-Aso M, Montesinos MC, Mediero A, Wilder T, Schafer PH, Cronstein B (2015) Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors
Important Safety Information Who shouldn't use these medications
Ulcerative colitis, Crohn's disease, celiac disease, and tendonitis
These outcomes suggest that the peptide not only contributes to longevity but also enhances quality of life in aging individuals
Any papers resulting from these two trials do not appear to be indexed in major global databases like PubMed, and its not clear if they were ever published in peer-reviewed journals
Interestingly, these studies showed differences in collecting the samples that may add an additional variability other than the well known variables, such as BMI, drugs, smoking, etc