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Mechanistically, impaired iron exporte.g., zinc-mediated inhibition of amyloid precursor protein (APP) ferroxidase activityprovides a route to local iron accumulation (Duce et al., 2010), while familial AD presenilin mutations confer selective vulnerability to ferroptosis in human neuronal models (Greenough et al., 2022)

Pushing that past its limit could potentially have long-term effects

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In muscle, Ddit4 induction and increases in mitochondrial DNA and cytochrome-c complement expression data

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Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA), have been proposed as potential contributors to the biology underlying ASD