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Semaglutide targets one specific hormone pathway, while tirzepatide is a dual-action drug targeting both GLP-1 and GIP receptors

The GH axis contributes to sleep architecture, cognitive function, energy metabolism, skin integrity, and mood regulation, all of which shift during perimenopause

This combination could theoretically increase the risk of acute kidney injury in susceptible individuals

Skin looks duller or slightly worse for a couple of weeks

Most (59%) of the biggest employers (at least 5,000 workers) offering the drugs for weight loss say their cost has exceeded expectations, and two-thirds (66%) say that they had a significant impact on their health plans prescription drug spending

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