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Examples of other 3D culture systems include RPTEC/TERT1 and Nki-2 cells that, when cultured in Matrigel or Matrigel mixed with collagen I, respectively, were able to further mature and form tubular structures as seen in vivo

The increased oxidation of estrogens does not seem to result in increased estrogen DNA-adduct formation, suggesting that these molecules do not mediate the carcinogenic effect of COCs

Consequently, further studies are needed to accurately examine tissue distribution in humans following oral curcumin intake