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A fully functional MTHFR with the assistance of B2, B6, and B12 (methylcyanocobalamin) helps methylate Hcy, recycling methionine (see Figure 4 )

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For native IGF-1, binding to IGFBP-3 and ALS lengthens circulating half-life the ternary complex protects the peptide from rapid renal clearance and proteolysis, so bound native IGF-1 persists in blood for hours rather than the roughly 10 minutes reported for free IGF-1

Reflective Questions Have you considered how your daily diet influences your antioxidant levels

Knowing which metric moved, and whether it rose above baseline or only fell more slowly, is what separates a lasting result from a temporary one, which is also why measuring brain aging across several markers at once gives a steadier read than any single number

doi: 10.1038/s41564-018-0334-0 136 LaichalkLLThorley-LawsonDA