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While their primary indications and mechanisms may vary (Figure 5), their ability to favorably influence the redox balance, as supported by the clinical studies on biomarkers and surrogate endpoints listed in Table 1, contributes to their overall beneficial effects

Historically, functional tests such as grip strength, walking speed, chair rising, and standing balance times were most commonly used in such studies (Ferrucci et al., 2016)

GLP-1RAs can suppress foam cell formation by activating GLP-1R signaling induced autophagy [134], reducing ACAT1 expression/activity [93], as well as inhibiting the PKA/CD36 pathway to inhibit ox-LDL uptake [135]

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12 Centers for Disease Control and Prevention (CDC)Subcutaneous injection technique: angle, site and no-aspiration guidance