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Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treated with fumaric acid esters

Ile 17 MAR709 experiments have tested the concurrent substitution of Gln 17 , Ala 18 , and Ala 19 from GLP-1 to Ile 17 , His 18 , and Gln 19 from GIP, and found that GLP-1 activity decreased (EC 50 : 0.022 nM0.140 nM) while that of GIP scarcely increased (EC 50 : 6.258 nM5.530 nM)

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Despite some individual studies reporting small benefits, more methodologically rigorous trials failed to show meaningful effects

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