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Randomized phase II study of FOLFOX+/ MET inhibitor, onartuzumab (O), in advanced gastroesophageal adenocarcinoma (GEC) [abstract]

Carnitine synthesis requires gamma-butyl betaine hydroxylase, and premature infants have a limited capacity to synthesize L-carnitine themselves, having only 1215% of the synthesis ability of adults ( 3.2 L-carnitine levels in preterm infants Due to the large transfer of maternal L-carnitine to the fetus in the third trimester and the immature mechanism of carnitine transport in premature infants, the blood level of l-carnitine in premature infants after 3 to 7 days is slightly higher than that in full-term infants ( Consequently, despite the potential for higher initial blood levels, the inherent physiological immaturity and reduced somatic mass associated with preterm birth mean that these infants have significantly diminished endogenous L-carnitine reserves

Open Forum Infect Dis 2022;9:ofac485.PubMedPMC REFERENCES PubReader ePub Link Cite this Article Cite this Article Close Download Citation Close XML Download Figure Fig

Every other week dosing is considered an off-label practice as the FDA has not approved it

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