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PMID 29898649 Sikiric P, Seiwerth S, et al

The CRL S23 line did not display any significant CYP3A4 activity/inducibility upon challenge with Rifampicin and indeed had much lower basal CYP3A4 activity levels compared with the other successful lines (Fig

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10.1681/ASN.2016010098 J Am Soc Nephrol

A trial could plausibly show sustained appetite suppression and weight loss (the appetite arm holding) alongside a fading gastric-emptying delay (the motor arm adapting)

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