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Human Reproduction , 27(12), 3412-3416

The animals were kept in a 12-hour light/dark cycle and maintained on standard rat laboratory chow and tap water ad libitum

I doubt the statistics in the USA would prove to be different

If timing precision feels overwhelming or your schedule makes consistent administration genuinely impossible, evening dosing (810 PM) offers the most forgiving window

Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme

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