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This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses

FDA has accepted a New Drug Application (NDA) for deucravacitinib, a potential "first-in-class" oral selective TYK2 inhibitor, for the treatment of adults with moderate/severe plaque psoriasis

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= 0.2 Z (1-2) = 1.96