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In rat cortical neuronal cultures, 9 -THC and cannabidiol, a nonpsychoactive component of Cannabis sativa, exhibited antioxidant activity and reduced glutamate toxicity by cannabinoid receptor-independent mechanism (Hamp-son et al., 1998)
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Therefore, this study investigated the metabolic profiles of patients with MMA carrying MUT mutations to identify candidate biomarkers and altered pathways that may improve our understanding of MMA pathophysiology and support future diagnostic applications
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